Ryogen Patents
Dr. James Ryan, who sequenced the gene XPNPEP2 that codes for an important protein, membrane-bound aminopeptidase P (AmP), has received US Patent No. 6,399,349 entitled “Human Aminopeptidase P Gene”.
This gene is a significant marker for hypertension, angioedema, rejection of kidney transplants, certain tumors and other diseases. This valuable patent covers cDNA and gDNA sequences coding AmP, a method of producing AmP, the diagnostics for detecting AmP abnormalities, and prevention and treatment of medical conditions associated with the mutation of the AmP gene.
US Patent No. 7,273,718, entitled "Isolated Genomic Polynucleotide Fragments from Chromosome 10q25.3 that Encode Human Soluble Aminopeptidase P", was issued on September 25, 2007.
The '718 patent covers an isolated genomic polynucleotide fragment that encodes human soluble (cytosolic) aminopeptidase P, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions, as well as antisense oligonucleotides to these fragments, and methods of using these fragments to obtain human soluble aminopeptidase P to diagnose, treat, prevent and/or ameliorate a pathological disorder.
Patent applications currently pending before the US Patent and Trademark Office are directed to other genes playing important roles in various cancers, diabetes and obesity, hepatitis C, atherosclerosis, Alzheimer’s and several other diseases.